Comments and Questions:

Comments: Ischemic stroke is a major cause of death and disability around the world due to brain injury and pathological alteration . Many researchers have tried to study the underlying mechanisms from different approaches. In this paper, the authors aimed at a novel target, the low-density lipoprotein receptor–related protein 4(LRP4) of astrocyte. Using knockout mice and other experiments, authors testified the hypothesis that LRP4 can decrease the injury resulting from ischemic stroke and highlightd a new method to treat ischemic stroke.


  1. How can the ischemic injury be induced by photothrombosis?

  2. What is the method of ischemic injury in the figure 2?

  3. How about the effect of ischemic injury in the LRP4 knockout mice at the late stage of stroke

  4. What is the effect of ATP release on astrocyte in the discussion part of this paper?

  5. What is the effect of ATP on the prognosis of ischemic stroke?

  6. How did authors calibrate the extents of photothrombosis of different rodents?

  7. How did adenosine participate in the pathogenesis of brain infarction?

  8. How did authors differentially change the expression of LRP4 in neurons and astrocytes?

  9. What is the mechanism underlying LRP4-associated brain injury?

  10. What is the translational potential of this study?


2018-3-30 Literature Analysis

Xin-Chun Ye, et al. Astrocytic LLRP4 (Low-Density Lipoprotein Receptor–Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A2AR (Adenosine A2A Receptor) Signaling. Stroke. 2018 Jan;49(1):165-174. doi:10.1161/STROKEAHA. 117.018115/-/DC1. PMID:29212737. Presented by Dongyang Li, Tong Li, Haitao Liu, Yang liu and Dan Cui.

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